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Understanding Your Semaglutide Dosing (5mg/mL in a 2.5mL Vial)
Understanding Your Semaglutide Dosing (5mg/mL in a 2.5mL Vial)

5mg per ML vs 2.5 mg per ML

Updated over a month ago

It can be tricky to understand how to measure the right dose from your vial, especially since the concentration (5mg/mL) might be different from what you’ve seen before. Let’s break it down step by step:

What does "5mg/mL" mean?

The concentration of your medication is 5 milligrams (mg) of semaglutide in every 1 milliliter (mL) of liquid. Your vial contains 2.5mL, so it holds a total of 12.5mg of semaglutide (5mg × 2.5mL).

When measuring your dose, you’ll be using a syringe marked in units (like an insulin syringe), not milliliters. Here’s how to figure out your dose:


Doses and Units

Use the following table to find the correct number of units for your prescribed dose:

Dose (mg)

Units to Draw

0.25mg

5 units

0.5mg

10 units

1mg

20 units

1.5mg

30 units

2mg

40 units

2.5mg

50 units


Why the Units Are Different for 2.5mg/mL vs. 5mg/mL

If your previous vial was 2.5mg/mL, the medication was less concentrated, meaning you needed twice as many units to get the same dose. For example:

  • 0.25mg dose with 2.5mg/mL: You needed 10 units.

  • 0.25mg dose with 5mg/mL: You now need 5 units.

The higher concentration (5mg/mL) means less liquid is required to get the same amount of medication, so you’ll draw fewer units with this vial.


Tips for Success

  • Double-check your dose: Always confirm your prescribed dose in milligrams and match it with the correct number of units.

  • Label your syringes: If you’re switching between concentrations, clearly mark the correct units for each vial to avoid confusion.

  • Ask for help if needed: If you’re unsure, reach out to your provider or pharmacist for clarification.

This guide should help you feel more confident in using your 5mg/mL vial. Remember, the higher concentration just means less liquid for the same dose—your actual medication amount hasn’t changed!

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